Dr. Jose Micabalo Oclarit

Dr. Jose Micabalo Oclarit

Scientist and Professor National Academy of Science and Technology

Dr. Jose Micabalo Oclarit
LAB

LAB

Scientist and Professor National Academy of Science and Technology

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The Cells

The Cells

Healthy and Damaged Cells

The Cells
The Lecture

The Lecture

Scientist and Professor National Academy of Science and Technology

The Lecture

The Molecular Mechanism of Cancer: How to prevent or treat through scientific interventions

BY: DR. JOSE M. OCLARIT
Fats are termed as triglycerides. Meaning there is one glycerol (a form of alcohol) and three fatty acids for one molecule of fat. Glycerol is then converted into glucose too, and those fatty acids are also converted into sugar via gluconeognenesis. Therefore, you can produce more blood sugar from taking fatty foods than carbohydrates or other sources. That is why people who eats litson most of the time becomes diabetic too. BEWARE OF THIS. FATS COULD SUPPLY 4x as much sugar than carbohydrates and proteins. This explains why there are so many diabetics nowadays.
Cancer cannot begin with a single mutation. It must take at least several mutations or cell aberrations before it can begin a neoplasm or tumor or cancel cell. This is so because, our very own cells have repair enzymes that can correct whatever errors that may occur at the DNA level. Thanks to DNA polymerase I which as a proof reading mechanism to decipher errors in replication and transcription. It can also synthesize new nucleotides as replacements. The younger and healthier our cells are the better is our coping mechanism to repair damage DNA or cell parts. The older we become, the lesser is our capacity to repair due to decreasing order of Glutatione level. Therefore, it is then important to maintain a healthy level of glutathione in our cells to prevent cellular and genetic damages.
With these knowledge, it is no wonder that cancer sets in at a later date of human life. Life begins at 40, because at this age, we start to deteriorate. Decrease of Glutatione is brought about by decrease in L-Cysteine and the magnitude of decrease is 1% every year emanating at age 20 years old or so.
The importance of Glutatione is that it is the most potent and powerful anti-oxidant in the human history. But why do we need anti-oxidant? We need it because as the cell metabolizes, there are so many free radicals that are formed. Added to this, are the free radicals due to exposure to cosmic radiations such as x-rays, gamma rays, UV, muons, pions, nutrinos and others.
What can we do?
1. drink plenty of water in a day 6-10 glasses. Water can protect us from the radiation damage at least 30% of the time.
2. take L-cysteine to increase Glutatione level. Vital White is a better brand.
3. Take megadose of vitamin C a day at least 15g/ day for busy people, or 5 grams sodium ascorbate for non-busy people.
4. Eat plenty of green leafy and colored vegetables. They are rich in carotene, xanthophylls, and cyanophylls. These are very potent antioxidants.
5. live a simple way of life.
6. go back to original diet as prescribed in Genesis 1:29
7. Trust in God - this is NO. 1 and more powerful.
HERE IS THE SCIENTIFIC EXPLANATION. WITH CONTINUOUS EATING ... THERE WILL BE INCREASE LEVEL OF INSULIN.... AND CONSEQUENTLY THE RELEASE OF IGF-1 WHICH RESULTS OF CASCADES OF METABOLIC ACTIVITIES...WHICH CAUSE RAPID WEAR AND TEAR OF MITOCHONDRIA AND CAUSES IT TO REGRESS AND EVENTUALLY DIE...THUS SHORTENING THE CELL CYCLE SPAN THUS RAPID AGEING.
As revealed in experiments with goat, when it is under severe stress, the vitamin C requirement of the goat is raised from 13 grams to 100 grams per day. That is 13,000 to 100,000 mg per day or equivament to 200 capsules of vital C a day. This result is consistent with the findings of Dr. Klenner and Catchart that a cancer patient
can take as highs as 150 grams of alkaline vitamin C (i.e., equivalent to 300 capsules per day). To remove the bulk, one can just get the crystalline vitamin c from the capsule and dissolve it on a glass of water and drink at least 25 g per dose. This is very effective against cancer of any kind. 



So my advise is: for cancer patients you can multiply 2 g x 10 or 2g x 100 = to make a megadose treatment. It is indeed very effective in dreaded diseases.

You can rest on the fact that there is 100 % bioavailability of alkaline vitamin C in the GIT and other parts of the body, therefore, there is no toxicity, provided, proper hydration is done by the patient. Drink plenty of water.
These are unsaturated fats that are good for the heart. They are liquid at room temperature, thus, it does not cause clogs in blood vessels. Example s DHA and EPA. TAKE THESE FROM PLANT MATERIALS LIKE OLIVE OIL, SUNFLOWER OIL, SOYBEAN OIL, CORN OIL AND OTHER PLANTS.
CELL-RECEPTORS ARE MAINLY MADE OF GLYCOPROTEINS WHICH ARE EASILY TAKEN FROM MEAT AND MEAT PRODUCTS. PLANT GLYCOPROTEINS ARE LESS LIKELY TO INFLUENCE BECAUSE IT HAS TO UNDERGO RIBOSOMAL PROCESSING DUE TO ITS DIFFERENT AMINO ACID COMPOSITION COMPARED TO ANIMAL PROTEINS WHICH HAVE HIGH HOMOLOGIES TO MAN'S OWN PROTEINS. OF COURSE ALL AMINO ACIDS PASS THROUGH THE SAME PATHWAY OF PROTEIN SYNTHESIS THROUGH THE RIBOSOMES.
Cancer of the Liver is one of the most dreaded cancers in the world today. There is slim chance of being arrested. Early detection might be better for any intervention. ... e.g. alkaline Vitamin C as practiced by many holistic medicine practicioners. Take Alkaline Vitamin C every day no less than 5 grams a day or 10 capsules/day.
70% OF CALCIUM IN THE BLOOD IS USED BY THE BODY TO SHUTTLE OUT NITROGENOUS WASTES FROM MEAT. SO, MEAT EATING MAY CAUSE LOW CALCIUM LEVEL IN THE BODY - THUS MAY CAUSE DEMINERALIZATION OF OUR BONES ... WHICH LEADS TO OSTEOPOROSIS. WATCH OUT THE DANGERS OF MEAT EATING.
By one estimate, the average human body produces more than two hundred trillion trillion (2 x 1026) molecules of ATP each day.

And the more we eat the more we produce ATP but... might be deleterious because of increase entropy. This phenomenon results to rapid aging. So less, eating less entropy... which may lead to delayed aging. This means that fasting is a very good health practice. 

HEALTH ADVICE: PRACTICE FASTING ONE DAY IN A WEEK - WILL GIVE 50 REJUVENATING DAYS IN A YEAR. 50 X 52 WEEKS = 2600 DAYS. THIS IS SO HEALTHFUL.
Cholesterol and fats are two different things. Fats and oils are the same, so when you talk of palm oils they are not the same as cholesterols.
Cholesterols are not at all bad when there is no LDL or Low Density Lipoproteins. It is the LDL that carries the cholesterol in the bloodstream and may be deposited into the walls of the blood vessels if the latter are inflamed. But what causes inflammat...ion of blood vessels? One primary causes of inflammation of blood vessels is chronic lack of alkaline vitamin C. Once the walls of blood vessels (the so called endothelium) are inflamed then the LDL-cholesterol complex is then deposited and causes the formation of fat streak and then later the clinical manifestation called ATHEROSCLEROSIS. From here many cardiovascular diseases will be manifested, e.g. Hypertension, heart murmurs, heart valve defects, rheumatic heart, thrombosis, heart enlargement, ischemia, stroke, myocardial infarction and many more. It all starts with chronic lack of vitamin C. Thus, IT CALLS FOR REGULAR TAKING OF ALKALINE VITAMIN C ON A DAILY BASIS AT LEAST 3 grams.
Palm oils are rich in palmitic fatty acids which are saturated oils. It is dangerous to human health because it is solid at room temperature. It will then clog the blood vessels especially the capillaries which eventually causes low oxygen in tissues ... The so called ischemia.

However, since palm oils are medium chained fatty acids they are dealt with by emulsifiers such as the bile salts whic...h facilitates digestion of fats. Practically all oils can be emulsified including cholesterols but it takes longer time and too taxing to the pancreas. That is why people who are meat eaters and fat lovers, will likely develop cancer of the pancreas - One fatal type of cancer nowadays. Take my advise AVOID FATTY FOODS.
Fats are termed as triglycerides. Meaning there is one glycerol (a form of alcohol) and three fatty acids for one molecule of fat. Glycerol is then converted into glucose too, and those fatty acids are also converted into sugar via gluconeognenesis. Therefore, you can produce more blood sugar from taking fatty foods than carbohydrates or other sources. That is why people who eats litson most of the time becomes diabetic too. BEWARE OF THIS. FATS COULD SUPPLY 4x as much sugar than carbohydrates and proteins. This explains why there are so many diabetics nowadays.
The mechanism of glucose, amino acids, fatty acids and other large charged molecules ---- they enter into the blood stream through the brush border of the intestine and it is by way of co- transport mechanism. Meaning there is no absorption of these molecules without sodium ion. Thus eating too much salty foods makes one diabetic because of the rapid transport of glucose across the brush border of the intestines. AVOID SALTY FOODS. IT COULD MAKE ONE DIABETIC TOO.
The second mechanism for the development of DM Type II is the possible destruction or damage to receptors due to over-eating of too much sugar. Here is the molecular mechanism: when food intake is high in carbohydrates (those highly processed like refined flour and refined sugar), there is rapid release of insulin from the beta-cells of the Islets of Langerhans of the pancreas, thus rapid bombar...dment of insulin receptors which would result to damage. When this happens insulin receptors become few if not nil and therefore could manifest in diabetic conditions. But since receptors can be repaired especially when there is considerable decrease in carbohydrate intakes, then, DM type II is easily reversible by change in lifestyle. Also, since receptors can be synthesized, time will come when these are all restored and the patient become normal again. But it takes at least 2-3 years for some receptors to be restored. No matter how slow, it is truly reversible. This is a promise of hope that people with diabetes mellitus type II can be normalize again.
What might be the cause of Diabetes Mellitus Type II? Every molecule that interacts with cell or tissues has its own receptor from which they interact with the cell to make appropriate reactions or actions. Insulin being a peptide hormone does not enter inside the cell. It only operates with the cell-signaling mechanism, so, insulin has its own receptor outside the membrane of the cell. Think ...for a moment where excess sugar is sequestered? It is largely in the liver, muscles, and adipose tissues. Once sugar is high in the blood, insulin is released and touches the receptor of those tissues mentioned and then trigger the opening of sugar channels and through active transport, sugar is then entered into the cell for transformations into glycogen or fats.

Now, when receptors are blocked, insulin cannot bind - thus, sugar is not sequestered. This will definitely cause DM Type II. That means, people with DM Type II has insulin release but receptors are not recognised due to some proteins or glycoproteins that blocked the receptor. In our study, most proteins and or molecules that block the receptors of insulin are coming from meat and meat products, therefore, eating too much meat is one of the causes of Diabetes Mellitus Type II. BEWARE. STOP EATING MEAT, THE PROCESS COULD BE REVERSED.

TAKE SODIUM ASCORBATE, AS THIS IS WELL-KNOWN CHELATORS THAT REMOVES TOXINS FROM RECEPTORS.
TAKING SODIUM ASCORBATE IS THEREFORE VERY EFFECTIVE IN REVERSING DM TYPE II.
Children below 10 years old must never be given any form of antibiotic because the first 10 years of life is crucial period of immune system development. After this period, limited forms of vaccines may be given. But slight exposures to some form of diets may act as vaccine or a vaccine in itself. Those children that were exposed to antibiotics below 10 years are vulnerable to heavy or chronic infections.
About 50 to 80% of nutrients are destroyed when foods are cooked. Except for Vitamin C which is totally destroyed, majority of these nutrients are reconstructed through the human metabolic systems. But overloading our system with highly polymerized foods can also result to over secretion of pancreatic enzymes thus causing enlargement of pancreas and may induce cancer. Meat eaters are likely to suffer this fate. This is a warning to people who are meat eaters. If meat has to be in a diet it must be clean lean meat but only once in a "blue moon".
VACCINATION AMONG CHILDREN FROM 0-10 YEARS OLD IS NOT NECESSARY. INSTEAD, IT IS RECOMMENDED THAT A CHILD MUST BE GIVEN ONE GRAM OF SODIUM ASCORBATE A DAY UP TO 10 YEARS OLD IN ORDER TO AVOID ALL FORMS OF CHILDHOOD DISEASES.
In the brush border of the intestines there is no absorption of glucose, amino acids, and fatty acids without sodium ions. This explains the reason why salt is needed in our diet in order to facilitate absorption of nutrients. Salt here is sodium chloride in particular. The transport mechanism in this process is called the co-transport system at the cellular level.

In this regard, when we take sodium ascorbate... It will drag some glucose molecules too at cellular level especially in the liver and muscle cells. So, taking sodium ascorbate can lower blood glucose in diabetic patients even without taking insulin or analogues of insulin.
Let us differentiate GELATIN from VEGECAP. Gelatin is an animal product usually derived from the digestion of collagen then polymerized into gelatin -- while vegecap comes from methly cellulose which is an analogue to carageenan, a plant material.
It is then not wise to take GSH orally because it will be degraded in the stomach by action of the proteases and on to duodenal area by pancreatic releases. We just have to take booster (L-cysteine) for our body to produce GSH or Glutathione
Don't you know that, Glutathione has a half-life of only 8 minutes in solution? So, even if taken intravenously - it has little effect as an anti-oxidant but has good effects for whitening because with GSH intact in the surface, it will inhibit melanin synthesis.
Eating much food has the same damaging effects as alcohol drugs because with rapid degradation of food, there will be plenty of metabolic free radicals (R.O.S.). ROS had profound damaging effects to mitochondria.
Don't you know that telomeres are the ones that control the life cycle of every tissue or cell lines in the body. When they are gone, the cell shifts to apoptosis or programmed cell death. To reduce or delay the telomere shortening, practice one day fasting per week.
An amino acid proline in the presence of sodium ascorbate is converted into hydroxyproline which is an important component of collagen. So, the more we take ascorbate (mineral form), the more collagen with have in all our systems. This will protect us from microbial infection and others.
SINCE GLUTATHIONE IS INTRACELLULARLY PRODUCED BY THE HUMAN BODY, IT IS CORRECT TO SAY THAT IT IS PART OF THE NATURAL METABOLISM THAT ESTABLISHES STRONG HOMEOSTATIC BALANCE FOR MAINTAINING GOOD HEALTH. ANENT THIS MATTER... IT IS CONCLUDED THAT THE AMOUNT OF GLUTATHIONE IN BODY IS PREDICTIVE OF HOW LONG WE LIVE.
WHAT IS THE IMPORTANCE OF HIGHER PH? HUMAN CELL NEEDS TO MAINTAIN AT LEAST 7.4 PH IN ORDER TO FUNCTION OPTIMALLY. AT THIS PH NO CANCER CELLS CAN EVER GROW, THEY ETIHER BECOME DORMANT AT FIRST AND LATER ON DISINTEGRATE. AT THIS PH - T CELLS AND B CELLS ARE PRODUCED ABUNDANTLY
Exogenous Glutatione is not advisable because is trimeric composed of 3 amino acids: glutamic acid + glycine + cysteine. When taken orally it is digested by proteases thus, it goes back to elemental form.


What the human body needs is Cystein in order to increase the amount of Glutathione in the body. Glutathione stands as the most powerful natural antioxidants that the human body can produce
Don't you know that the natural form of vitamin C is called the Mineral-Ascorbate. In essence all ascorbate in plants and producers are always attached to certain minerals depending on what kind of fruit or vegetables. The most common one is sodium ascorbate.


This brings to the idea that, vitamin C in the market is plain ascorbate or ascorbic acid. But the natural form of vitamin C is indeed, mineral-ascorbate, it could be Na-Ascorbate, K-ascorbate, Ca-ascorbate and many more.


The goat can produce 13 g of Vitamin C everyday, but could increase to 100 g/day if under stress. It goes without saying that the human body needs up to 100,000 mg per day when under stress and severe medical conditions.


Three reasons why Vitamin C and B can be taken megadoses: 
1. it is highly water soluble
2. it cannot be stored in any tissues of the body
3. left over amounts are easily removed through the kidney and flushed into the urine.



VITAMIN C OR MINERAL ASCORBATE NEEDS TO BE TAKEN IN LARGE DOSE BECAUSE THIS IS THE ONLY VITAMIN THAT IS EASILY DESTROYED BY HEAT, AIR AND PHOTONS OF LIGHT. THE HALF LIFE OF VITAMIN C IN SOLUTION IS ONLY 30 MINUTES - MEANING THE POTENCY IS REDUCED TO 50% EVERY 30 MINUTES.
MOST STATINS BLOCK CO-ENZYME 10 which activates metabolism especially in Electron transport system of the Inner membrane of the mitochondria. This explains why administering statins could cause muscle cramps for lack of ATP in the muscular and cellular levels. It is also the cause of muscle weaknesses and lethargy.


Statins is also the culprit why Myastenia graves is aggravated. MG is a neuro disorder characterized by inability of the receptor to recognize acetylcholine in the nerve endings, causes, paralysis of the phrenic nerves affecting heart and lungs. Be careful in taking these drugs. Take Vital C instead.
Neurophysiology of Multiple Sclerosis:
This disease is a neurodisorder affecting the degeneration of myelin sheaths that covers the nerves. When this happens, the nerves cannot transmit impulse onto the innervated muslces, thus, causing paralysis and numbness of affected areas. This is irrversible. That is why MS has no cure at the moment. But the goodnews is, if properly diagnosed earlier, it can be intervened. One strategy is increase intake of DHA or EPA (or any omega-3 compounds).


Here is my dosages for MS interventions:
1 capsule omega-3 / at 300 to 500 mg prep) per day
1 tablet Vitamin B complex 3x a day
3 capsules sodium ascorbate (Vital C) 3x a day for 6 months
Take lots of fresh juices
alternate carrot juicing every 3 days (not daily as it may cause hypervitaminosis A


Recent results of experiments, Sodium Ascorbate can increase the amount of neuro-transmitters, therefore, could increase impulse transmissions. Alkaline vitamin C can also facilitate synthesis of sphingosine which are components of nerves. So taking sodium ascorbate in tandem with omega-3 and Vitamin B complex is a a perfect intervention for MS.


Multiple Sclerosis has no known cure but since it is an Autoimmune Disorder it can be intervened by cleansing the cell receptors which may be clogged by extraneous proteins coming from meat-eating. One of the best chelators or cleansers is Sodium Ascorbate (the so called Alkaline Vitamin C). Added to this, administer Omega-3 as 60 percent of neurons are made of DHA. Take at least one capsule of omega-3 a day at 360 mg preparation. People with MS please read this!!!
The Real reason for developing MS is meat-eating. Why? Meats, fatty foods from animals and other meat products, can block cellular receptors of all types of cell lines in the human body. When this happens, our T cells and B Cells are activated to attack the cell with blocked receptors. This is the beginning of autoimmune attack causing denegeration of cells and muscles or nerves. The same mechanisms hold true to psoriasis and SLE (Systemic Lupus Erythematosus)
COOKING HAD BECOME A NECESSARY EVIL THAT HAS DESTROYED THE MOST FUNDAMENTAL SUPPLEMENT IN ALL THE WORLD. ALL THE OTHER VITAMINS ARE STABLE EVEN AFTER COOKING. THEREFORE, IT IS LOGICAL THAT WE THEREFORE HAVE GREAT DEFICIENCY OF VITAMIN C IN OUR FOOD. ISN'T CORRECT THEREFORE THAT WE SHOULD ENDEAVOR TO TAKE SODIUM ASCORBATE SEVERAL TIMES A DAY TO COMPENSATE FOR THE GENETIC DEFFECT.
LACK OF GULONOLACTONE GENE IS THE CULPRIT WHY HUMAN BODY CANNOT PRODUCE VITAMIN C. NOW CONSIDERING THAT VITAMIN C IS THE ONLY VITAMIN THAT IS EASILY DESTROYED BY HEAT, ATMOPHERIC AIR AND RADIATION, IT MUST BE REASONABLE THAT HUMAN BODY HAD GREATLY DETERIORATED OVER TIME. THEREFORE RESTORING MASSIVE DOSE OF VITAMIN C IS LOGICAL IF NOT ULTIMATE TO RESTORE MAN'S HEALTH AND WELL-BEING.
EDUCATING MEDICAL DOCTORS TO PRESCRIBE ALL PATIENTS WITH SODIUM ASCORBATE MAY THEREFORE GREATLY INCREASED SUCCESS OF MEDICAL THERAPEUTICS WITHOUT COMPLICATIONS BECAUSE VITAMIN C HAS NO TOXICITY AND SIDE EFFECTS.
I HAVE NO TEACHINGS IN MY LECTURES WHICH ARE NOT BACKED UP BY SCIENTIIFIC EVIDENCE, SO - --- PEOPLE ARE MORE CONVINCED OF THE EFFICACY OF SODIUM ASCORBATE IN REVERSING MANY DEBILITATING DISEASES IN HUMANS.


Dr. Jose M. Oclarit
Dr. Jose Micabalo Oclarit
Scientist & Professor
National Academy of Science & Technology

•Obtained his  PhD in Applied Biochemistry & Molecular Biology at Hiroshima University in Japan in 1994 as a Japanese Government Science Scholar  from 1990-1994

•Master of Science in Human Physiology as a National Science Scholar at the University of the Philippines, Diliman, Quezon City (1981-1987)

•He obtained three post doctoral degrees:

1.  in Molecular Genetics and
2.  on Fatty Acids

•both at the National Industrial Research Institute of the Agency of Science and Technology of Japan. 

•His 3rd post doctoral work in 2000-2001 was on Calcium Regulation. At that time He also served as a Medical Scientist at the Edward Hines Veterans Hospital in Chicago, Illinois, U.S.A. 

 •Awarded as an Outstanding Young Scientist of the Philippines (1996) by the National Academy of Science and Technology.

•At present there are only 262 outstanding scientists since its beginning  in 1980.

Recognized Scientist of the US State Department
Regular Visiting Scientist on Natural Products Chemistry at the University of California in Santa Cruz, California, U.S.A.

• Dr. Oclarit is acclaimed as one of the Who’s Who in the World of SCIENCE from 1996 up to present.

•He is an expert  in Genetic Engineering  and Natural Products chemistry of antibiotics  and molecular biology of antibiotic genes.

• A Pharmacognosy Consultant

•In Pharma Industry

•At present he is a Professor of Medicine at Southwestern University Cebu

His distinct contributions to science is his discovery of  two new compounds: 

1.one anticancer agent against human blood cells and the

2.other an antibiotic against Gram positive bacteria from which

He gained two international patents for the molecules he discovered. 

In year 2000, He also discovered an anti-tuberculosis drug and was awarded as the most Outstanding Researcher of the Department of Science and Technology.  

Dr. Oclarit has traveled and lectured in Biomedical Sciences to: 
The Netherlands, France, Belgium, Brussels, Bremen, Spain, Scotland, Belfast City-Northern Ireland, Dublin, Republic of Ireland, Germany, United States, Japan, Malaysia, Hongkong, Singapore, Dubai United Arab Emirates, Indonesia, Thailand, Bangladesh, and China.

Dr. Oclarit also serve as Health Adviser & Lecturer of the Health Department of the Southern Asia Pacific Division General Conference of the Seventh Day Adventist, Washington D.C.

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